Peer-Reviewed Papers

    2021

1. Wei YT, Wu JW, Yeh CW, Shen HC, Wu KP, Vida Imre, Lien CC. Morpho-physiological properties and connectivity of vasoactive intestinal polypeptide-expressing interneurons in the mouse hippocampal dentate gyrus . J. Comp. Neurol.  2021 (Published as Early View). [PDF] [PubMed]

    2019

1. Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC-derived neurons. Sci. Rep. 2019 Dec 17;9(1):19301. doi: 10.1038/s41598-019-55614-9. [PDF] [PubMed]

2. Hsu YT, Chang YG, Liu YC, Wang KY, Chen HM, Lee DJ, Yang SS, Tsai CH, Lien CC, Chern YJ.  Enhanced Na+-K+-2Cl- cotransporter 1 underlies motor dysfunction in Huntington's disease. Mov. Disord. 2019 Jun;34(6):845-857. (Co-corresponding author) [PDF] [PubMed]

    2018

1. Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol. Dis. 2018 Jan; 109(Pt A): 25-32. [PDF] [PubMed]

2. Martina M., Lien CC. (2018) Physiological Properties of Hippocampal Neurons. In: Cutsuridis V., Graham B., Cobb S., Vida I. (eds) Hippocampal Microcircuits. Springer Series in Computational Neuroscience. Springer, Cham. (co-corresponding author) [PDF] [Link]

    2017

1. Huang CY, Lien CC, Cheng CF, Yen TY, Chen CJ, Tsaur ML. K+ channel Kv3.4 is essential for axon growth by limiting the influx of Ca2+ into growth cones. J. Neurosci.  2017 April; 37(17): 4433-4449.
(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]

2. Kuo YL, Cheng JK, Hou WH, Chang YC, Du PH, Jian JJ, Rau RH, Yang JH, Lien CC, Tsaur ML. K+ channel modulatory subunits KChIP and DPP participate in Kv4-mediated mechanical pain control. J. Neurosci.  2017 April; 37(16): 4391-4404.
(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]   

    2016

1. Lee CT, Kao MH, Hou WH, Wei YT, Chen CL, Lien CC. Causal evidence for the role of specific GABAergic interneuron types in entorhinal recruitment of dentate granule cells. Sci. Rep. 2016 Nov; 6: 36885. (Corresponding author)

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [PubMed] [Supplementary Information]

2. Wu CC, Lien CC, Hou WH, Chiang PM, Tsai KJ. Gain of BDNF function in engrafted neural stem cells promotes the therapeutic potential for Alzheimer's disease. Sci. Rep. 2016 Jun; 6: 27358.

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [PubMed]

3. Hsu TT, Lee CT, Tai MH, Lien CC. Differential recruitment of dentate gyrus interneuron types by commissural versus perforant pathways. Cerebral Cortex 2016 Jun; 26(6): 2715-2727. (Corresponding author)

(Impact factor: 8.665; Rank: 16/252=6.35% in Neuroscience) [PDF] [Supporting information] [PubMed]

4. Hou WH, Kuo N, Fang GW, Huang HS, Wu KP, Zimmer A, Cheng JK, Lien CC. Wiring specificity and synaptic diversity in the mouse lateral central amygdala. J. Neurosci. 2016 April; 36(16): 4549-4563. (Corresponding author) (Featured Article)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]; also see Editor's Commentary [PDF] [PDF (Chinese Ver.)]

5. Chang CP, Lee CT, Hou WH, Lin MS, Lai HL, Chien CL, Chang C, Cheng PL, Lien CC*, Chern Y. Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning. Sci. Rep. 2016 Mar; 6(22529): 1-16. (*co-corresponding author)

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [Supporting information] [PubMed]

    2015

1. Chiang PH, Chien TC, Chen CC, Yanagawa Y, Lien CC. ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. Sci. Rep. 2015 May; 5: 10143. (Corresponding author)

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [Supporting information] [PubMed]

2. Lin SH, Chien YC, Chiang WW, Liu YZ, Lien CC, Chen CC. Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur. J. Neurosci. 2015 Jun; 41(12): 1553-1568.

(Impact factor: 3.181; Rank: 107/252=42.46% in Neurosciences) [PDF] [PubMed]

3. Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D mutation of Presenilin-1 reduces Pen2 interaction, increases Aβ42/Aβ40 ratio and elevates ER Ca2+ accumulation. Mol. Neurobiol. 2015 Dec; 52(3): 1835-1849.

(Impact factor: 5.137; Rank: 36/252=14.29% in Neuroscience) [PubMed]

    2014

1. Cheng CF, Cheng JK, Chen CY, Lien CC, Chu D, Wang SY, Tsaur ML. Mirror-image pain is mediated by NGF produced from tumor necrosis factor alpha-activated satellite glia after peripheral nerve injury. Pain 2014 May; 155(5): 906-920.

(Impact factor: 5.213; Rank: 2/30=6.67% in Anesthesiology) [PDF] [Supporting information] [PubMed]

2. Liu YC, Cheng JK, Lien CC. Rapid dynamic changes of dendritic inhibition in the dentate gyrus by presynaptic activity patterns. J. Neurosci. 2014 Jan 22; 34(4): 1344-1357. (Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]

    2013

1. Chan CF*, Kuo TW*, Weng JY*, Lin YC*, Chen TY*, Cheng JK, Lien CC. Ba2+- and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells. J. Physiol. 2013 Oct 1; 591(19): 4843-4858. (*: Co-First author;  Corresponding author)

(Impact factor: 5.037; Rank: 5/83=6.02% in Physiology) [PDF] [PubMed]; also see the perspective by Battefeld and Kole in the same issue; also selected as the Editor Choice in the same issue [PDF]

2. Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Hung KS, Lien CC, Kuan CY, Lee YH. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS ONE 2013 Jul 9; 8(7): e69019.

(Impact factor: 3.234; Rank: 8/56=14.29% in Multidisciplinary Sciences) [PDF] [Supporting information] [PubMed]

3. Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng IH, Lien CC. Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J. Neurosci. 2013 Jan 30; 33(5): 1828-1832. (Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]

    2012

1. Lee YC, Alexandra D, Majczenko K, Huang YH, Liu YC, Lien CC, Tsai PC, Ichikawa Y, Goto J, Monin ML, Li JZ, Chung MY, Mundwiller E, Shakkottai V, Liu TT,  Tesson C, Lu YC, Brice A, Tsuji S, Burmeister M, Stevanin G, Soong BW. Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann. Neurol. 2012 Dec; 72(6): 859-869.

(Impact factor: 9.977; Rank: 5/192=2.6% in Clinical Neurology) [PDF] [Supporting Information] [PubMed]

2. Majumder P, Chen YT, Bose JK, Wu CC, Cheng WC, Cheng SJ, Fang YH, Chen YL, Tsai KJ, Lien CC, Shen CK. TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta. Neuropathol. 2012 Aug; 124(2): 231-245. Epub 2012 Jul 4.

(Impact factor: 10.762; Rank: 4/192=2.08% in Clinical Neurology) [PDF] [Supplementary Material] [PubMed]

3. Chiang PH*, Wu PY*, Kuo TW*, Liu YC, Chan CF, Chien TC, Cheng JK, Huang YY, Chiu CD, Lien CC. GABA is depolarizing in hippocampal dentate granule cells of the adolescent and adult rats. J. Neurosci. 2012 Jan 4; 32(1): 62-67. (*: Co-First author; Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]

    2010

1. Lin YC, Liu YC, Huang YY, Lien CC. High-density expression of Ca2+-permeable ASIC1a channels in NG2 glia of rat hippocampus. PLoS ONE 2010 Sep 10; 5(9): e12665-e12672. (Corresponding author)

(Impact Impact factor: 3.234; Rank: 8/56=14.29% in Multidisciplinary Sciences) [PDF] [PubMed]

2. Chu KC, Chiu CD, Hsu TT, Hsieh YM, Huang YY, Lien CC. Functional identification of an outwardly rectifying pH- and anesthetic-sensitive leak K+ conductance in hippocampal astrocytes. Eur. J. Neurosci. 2010 Sep; 32(5): 725-735. (Corresponding author)

(Impact factor: 3.181; Rank: 107/252=42.46% in Neurosciences) [PDF] [Supporting Information] [PubMed]

3. Weng JY, Lin YC, Lien CC. Cell type-specific expression of acid-sensing ion channels in hippocampal interneurons. J. Neurosci. 2010 May 12; 30(19): 6548-6558. (Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [Supplemental Data] [PubMed]

4. Chiang PH, Yeh WC, Lee CT, Weng JY, Huang YY, Lien CC. M1-Like muscarinic acetylcholine receptors regulate fast-spiking interneuron excitability in rat dentate gyrus. Neuroscience 2010 Aug 11; 169(1): 39-51. Epub 2010 Apr 28. (Corresponding author)

(Impact factor: 3.357; Rank: 95/252=37.7% in Neurosciences) [PDF] [PubMed]

    2009

1. Liao CW, Lien CC. Estimating intracellular Ca2+ concentrations and buffering in a dendritic inhibitory hippocampal interneuron. Neuroscience 2009 Dec 29; 164(4): 1701-1711. Epub 2009 Sep 25. (Corresponding author)

(Impact factor: 3.357; Rank: 95/252=37.7% in Neurosciences) [PDF] [PubMed]

    2006

1. Aponte Y, Lien CC, Reisinger E, Jonas P. Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus. J. Physiol. 2006 Jul 1; 574(Pt 1): 229-243. Epub 2006 May 11.

(Impact factor: 5.037; Rank: 5/83=6.02% in Physiology) [PDF] [PubMed]

2. Lien CC, Mu Y, Vargas-Caballero M, Poo MM. Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat. Neurosci. 2006 Mar; 9(3): 372-380. Epub 2006 Feb 12.

(Impact factor: 16.095; Rank: 5/252=1.98% in Neuroscience) [PDF] [Supplementary Information] [PubMed]

    2004

1. Oliver D*, Lien CC*, Soom M, Baukrowitz T, Jonas P, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science (Research Article) 2004 Apr 9; 304(5668): 265-270. Epub 2004 Mar 18. (*equal contribution).

(Impact factor: 33.611; Rank: 2/56=3.57% in Multidisciplinary Sciences) [PDF] [Supporting Online Material] [PubMed]

    2003

1. Lien CC, Jonas P. Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J. Neurosci. 2003 Mar 15; 23(6): 2058-2068.

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]

    2002

1. Lien CC, Martina M, Schultz J, Ehmke H, Jonas P. Gating, modulation, and subunit composition of voltage-gated K+ channels in dendritic inhibitory interneurones of rat hippocampus. J. Physiol. 2002 Jan 15; 538(Pt 2): 405-419.

(Impact factor: 5.037; Rank: 5/83=6.02% in Physiology) [PDF] [PubMed]